Sentinel Lymph Node Detection Using Carbon Nanoparticles in Patients with Early Breast Cancer
| Autor: | Jianping Lu, Xiufeng Wu, Yi Zeng, Qingzhong Lin, Jun Yan, Gang Chen, Xia Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Injections Intradermal Breast surgery medicine.medical_treatment Science Sentinel lymph node Breast Neoplasms Pilot Projects Breast cancer Surgical oncology Biopsy medicine Carcinoma Humans Prospective Studies False Negative Reactions Aged Neoplasm Staging Multidisciplinary medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy Carcinoma Ductal Breast Middle Aged medicine.disease Carbon Methylene Blue Axilla Carcinoma Lobular medicine.anatomical_structure Lymphatic system Early Diagnosis Lymphatic Metastasis Nanoparticles Medicine Female Radiology Lymph Nodes business Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 8, p e0135714 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | PurposeCarbon nanoparticles have a strong affinity for the lymphatic system. The purpose of this study was to evaluate the feasibility of sentinel lymph node biopsy using carbon nanoparticles in early breast cancer and to optimize the application procedure.MethodsFirstly, we performed a pilot study to demonstrate the optimized condition using carbon nanoparticles for sentinel lymph nodes (SLNs) detection by investigating 36 clinically node negative breast cancer patients. In subsequent prospective study, 83 patients with clinically node negative breast cancer were included to evaluate SLNs using carbon nanoparticles. Another 83 SLNs were detected by using blue dye. SLNs detection parameters were compared between the methods. All patients irrespective of the SLNs status underwent axillary lymph node dissection for verification of axillary node status after the SLN biopsy.ResultsIn pilot study, a 1 ml carbon nanoparticles suspension used 10-15min before surgery was associated with the best detection rate. In subsequent prospective study, with carbon nanoparticles, the identification rate, accuracy, false negative rate was 100%, 96.4%, 11.1%, respectively. The identification rate and accuracy were 88% and 95.5% with 15.8% of false negative rate using blue dye technique. The use of carbon nanoparticles suspension showed significantly superior results in identification rate (p = 0.001) and reduced false-negative results compared with blue dye technique.ConclusionOur study demonstrated feasibility and accuracy of using carbon nanoparticles for SLNs mapping in breast cancer patients. Carbon nanoparticles are useful in SLNs detection in institutions without access to radioisotope. |
| Databáze: | OpenAIRE |
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