Metabolomics Investigation To Shed Light on Cheese as a Possible Piece in the French Paradox Puzzle
| Autor: | Janne K. Lorenzen, Mette Kristensen, Christian Clement Yde, Hanne C. Bertram, Arne Astrup, Morten Rahr Clausen, Hong Zheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent TMAO Urine Biology Creatine fermented dairy products chemistry.chemical_compound Young Adult Feces Cheese French paradox Choline Animals Humans Metabolomics Food science chemistry.chemical_classification Creatinine Cross-Over Studies Cholesterol cholesterol Lipid metabolism General Chemistry Middle Aged SCFA urine Milk chemistry Propionate Metabolome Cattle General Agricultural and Biological Sciences |
| Zdroj: | Zheng, H, Yde, C C, Clausen, M R, Kristensen, M, Lorenzen, J, Astrup, A & Bertram, H C S 2015, ' Metabolomics Investigation To Shed Light on Cheese as a Possible Piece in the French Paradox Puzzle ', Journal of Agricultural and Food Chemistry, vol. 63, no. 10, pp. 2830-2839 . https://doi.org/10.1021/jf505878a |
| DOI: | 10.1021/jf505878a |
| Popis: | An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on blood cholesterol level. Fifteen healthy young men participated in a full crossover study during which they consumed three isocaloric diets with similar fat contents that were either (i) high in milk, (ii) high in cheese with equal amounts of dairy calcium, or (iii) a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate, and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine, and creatinine levels and significantly increased the microbiota-related metabolites butyrate, hippurate, and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level. |
| Databáze: | OpenAIRE |
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