Prepregnancy plant-based diets and the risk of gestational diabetes mellitus
| Autor: | Frank Qian, Jorge E. Chavarro, Qi Sun, Gang Liu, Cuilin Zhang, Shilpa N Bhupathiraju, Zhangling Chen, Deirdre K Tobias, Mengying Li, Sylvia H. Ley, Trudy Voortman, Frank B. Hu, Ling-Jun Li |
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| Přispěvatelé: | Epidemiology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Risk
medicine.medical_specialty Singleton pregnancy Medicine (miscellaneous) Lower risk SDG 3 - Good Health and Well-being Pregnancy Risk Factors medicine Humans Prospective Studies Prospective cohort study Generalized estimating equation Nutrition and Dietetics business.industry Obstetrics Medical record Plant based Plants medicine.disease Diet Gestational diabetes Diabetes Gestational Original Research Communications Female business |
| Zdroj: | American Journal of Clinical Nutrition, 114(6), 1997-2005. American Society for Nutrition Am J Clin Nutr |
| ISSN: | 0002-9165 |
| Popis: | Background: Emerging evidence suggests beneficial impacts of plant-based diets on glucose metabolism among generally healthy individuals. Whether adherence to these diets is related to risk of gestational diabetes mellitus (GDM) is unknown. Objectives: We aimed to examine associations between plant-based diets and GDM in a large prospective study. Methods: We included 14,926 women from the Nurses' Health Study II (1991-2001), who reported ≥1 singleton pregnancy and without previous GDM before the index pregnancy. Prepregnancy adherence to plant-based diets was measured by an overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), and unhealthful plant-based diet index (uPDI) as assessed by FFQs every 4 y. Incident first-Time GDM was ascertained from a self-reported physician diagnosis, which was previously validated by review of medical records. We used log-binomial models with generalized estimating equations to calculate RRs and 95% CIs for associations of PDIs with GDM. Results: We documented 846 incident GDM cases over the 10-y follow-up among 20,707 pregnancies. Greater adherence to the PDI and hPDI was associated with lower GDM risk. For the PDI, the multivariable-Adjusted RR (95% CI) comparing the highest and lowest quintiles (Q5 compared with Q1) was 0.70 (0.56, 0.87) (Ptrend = 0.0004), and for each 10-point increment was 0.80 (0.71, 0.90). For the hPDI, the RR (95% CI) of Q5 compared with Q1 was 0.75 (0.59, 0.94) (Ptrend = 0.009) and for each 10-point increment was 0.86 (0.77, 0.95). After further adjustment for prepregnancy BMI, the associations were attenuated but remained significant: for the PDI, the RR (95% CI) for each 10-point increment was 0.89 (0.79, 1.00) and the corresponding RR (95% CI) was 0.89 (0.80, 0.99) for the hPDI. The uPDI was not associated with GDM. Conclusions: Our study suggests that greater prepregnancy adherence to a healthful plant-based diet was associated with lower risk of GDM, whereas an unhealthful plant-based diet was not related to GDM risk. |
| Databáze: | OpenAIRE |
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