The Scottish First Episode Schizophrenia Study V. One-year follow-up. The Scottish Schizophrenia Research Group
| Autor: | Norman A. Todd, David H. Wiles, John Loudon, James A. G. Watt, J. G. Greene, Alistair E. Philip, Angus M. Scott, David Batchelor, Martin G. Livingston, Robin G. McCreadie, Peter W. Kershaw, George T. Crocket, Zahid Mahmood, John W. Moore, Stewart M. Grant, James A. T. Dyer |
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| Rok vydání: | 1988 |
| Předmět: |
Pediatrics
medicine.medical_specialty One year follow up Tardive dyskinesia First episode schizophrenia 03 medical and health sciences 0302 clinical medicine Pimozide Cognition Maintenance therapy Adaptation Psychological Medicine Humans Family Interpersonal Relations 030212 general & internal medicine Social functioning business.industry Flupenthixol decanoate medicine.disease Prognosis 030227 psychiatry Flupenthixol Hospitalization Psychiatry and Mental health Tranquilizing Agents Scotland Thioxanthenes Schizophrenia Schizophrenic Psychology Schizophrenia research business Social Adjustment medicine.drug Follow-Up Studies |
| Zdroj: | The British journal of psychiatry : the journal of mental science. 152 |
| ISSN: | 0007-1250 |
| Popis: | Of 49 schizophrenic patients followed up 12 months after their first admission to hospital, only about 45% had experienced no relapse and had no schizophrenic symptoms; a poorer outcome was more often found in Feighner positive than Feighner negative schizophrenic patients. The patients' overall level of unemployment had more than doubled to 51%. In patients whose acute episodes responded to treatment, pimozide taken once weekly as maintenance therapy was as effective as intramuscular flupenthixol decanoate, but tardive dyskinesia appeared in two patients receiving weekly pimozide; the repeat psychometric assessment at 12 months found modest improvements, i.e. no evidence of intellectual decline, in Matrices, Block Design, and Digit Copying tests. Forty per cent of relatives still showed significant psychological distress, which correlated with patients' schizophrenic symptoms, and the relatives' social functioning remained poorer than that of a normal community sample. |
| Databáze: | OpenAIRE |
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