The pharmacokinetics of linezolid in the non-inflamed human eye
| Autor: | A.R. Watts, D R Jenkins, J I Prydal, A Lovering |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.drug_class medicine.medical_treatment Gram-positive bacteria Antibiotics Clinical Science - Scientific Reports Cataract Extraction Aqueous Humor Cellular and Molecular Neuroscience chemistry.chemical_compound Endophthalmitis Pharmacokinetics Acetamides medicine Humans Antibiotic prophylaxis Gram-Positive Bacterial Infections Oxazolidinones Aged Aged 80 and over biology business.industry Linezolid Antibiotic Prophylaxis Middle Aged Cataract surgery biology.organism_classification Antimicrobial medicine.disease Sensory Systems Anti-Bacterial Agents Ophthalmology chemistry Anesthesia Female business |
| Zdroj: | British Journal of Ophthalmology. 89:1418-1419 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2005.073700 |
| Popis: | Aim: This study describes the ocular pharmacokinetics of linezolid, an antibiotic with broad spectrum activity against those Gram positive bacteria that are the most frequent cause of postoperative endophthalmitis. Method: Patients undergoing routine cataract surgery were given a single oral 600 mg dose of linezolid at a variable time before surgery. Aqueous and serum levels of linezolid were assayed by high performance liquid chromatography, and a pharmacokinetic curve constructed from the pooled results. Results: Orally administered linezolid rapidly achieves levels in the aqueous of non-inflamed eyes that exceed the concentration required to kill Gram positive bacteria (maximum mean concentration 6.8 (SD 1.2) µg/ml at 2–4 hours post-dose). An effective concentration is maintained for at least 12 hours, the standard interdose interval for this antimicrobial. Conclusion: Linezolid offers the possibility of a rapid, oral approach to effective treatment of most cases of postoperative endophthalmitis, with the potential of improving visual outcome. |
| Databáze: | OpenAIRE |
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