Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease
| Autor: | Cristina Airoldi, Francesco Nicotra, Barbara La Ferla, F Ornaghi, Francisco Cardona, Laura Colombo, Giulio Sancini, Erika Sironi, Ilaria Cambianica, Mario Salmona |
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| Přispěvatelé: | Airoldi, C, Cardona, F, Sironi, E, Colombo, L, Salmona, M, Cambianica, I, Ornaghi, F, Sancini, G, Nicotra, F, LA FERLA, B |
| Rok vydání: | 2013 |
| Předmět: |
fluorescent derivative
Chemistry Ligand General Chemical Engineering General Chemistry Diagnostic tools Stain Fluorescence Amyloid β peptide In vitro model Benzopyran chemistry.chemical_compound Binding ability Biochemistry BIO/09 - FISIOLOGIA CHIM/06 - CHIMICA ORGANICA Aβ-peptide ligand glycofused compounds Alzheimer’s disease |
| Zdroj: | Pure and Applied Chemistry. 85:1813-1823 |
| ISSN: | 1365-3075 0033-4545 |
| DOI: | 10.1351/pac-con-12-11-07 |
| Popis: | Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluorescently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood–brain barrier (BBB) and to stain Aβ‑deposits. |
| Databáze: | OpenAIRE |
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