CD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART
| Autor: | Hui Shao, Jie Li, Jian-Ping Zhong, Wen-fang Xu, Heping Rao, Yong Wu, Qiu-qiong Lv, Jian-kang Zhou |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Naive T cell Anti-HIV Agents T-Lymphocytes Clinical Biochemistry HIV Infections chemical and pharmacologic phenomena Flow cytometry Interleukin-7 Receptor alpha Subunit Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases Antiretroviral Therapy Highly Active medicine Humans 030212 general & internal medicine Fluorescein isothiocyanate Interleukin-7 receptor Aged Allophycocyanin medicine.diagnostic_test biology Cluster of differentiation business.industry Biochemistry (medical) virus diseases hemic and immune systems Middle Aged Flow Cytometry 030104 developmental biology medicine.anatomical_structure chemistry Immunology biology.protein Female business Memory T cell Phycoerythrin |
| Zdroj: | Laboratory Medicine. 48:57-64 |
| ISSN: | 1943-7730 0007-5027 |
| DOI: | 10.1093/labmed/lmw053 |
| Popis: | Objective: To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression. Methods: We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4+T 600/µL). Counts and percentages of naive (CD45RA+) and memory (CD45RO+) T cells and CD127 expression were determined using flow cytometry. Results: CD4+CD45RO+, CD4+CD45RA+, CD4+ CD45RO+ CD127+, and CD4+CD45RA+CD127+T-cell counts in patients with good recovery were higher than in patients with poor recovery and those with general recovery patients ( P |
| Databáze: | OpenAIRE |
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