Cognitive Impairment in the Lateralized Phenotype of Corticobasal Degeneration
| Autor: | Giuseppe Cazzato, Tatiana Cattaruzza, Rita Moretti, Rodolfo M. Antonello, Paola Torre |
|---|---|
| Přispěvatelé: | Moretti, Rita, Torre, P, Antonello, Rm, Cattaruzza, T, Cazzato, G., Pizzolato, Gilberto |
| Rok vydání: | 2005 |
| Předmět: |
Male
Movement disorders brain Cognitive Neuroscience Neuropsychological Tests cbd lateralization Basal Ganglia Functional Laterality Memory medicine Humans Corticobasal degeneration Dementia Neuropsychological assessment Aged Cerebral Cortex Psychiatric Status Rating Scales Behavior medicine.diagnostic_test Cognitive disorder Cognitive flexibility Neurodegenerative Diseases Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Treatment Outcome Disease Progression Anxiety Female Geriatrics and Gerontology medicine.symptom Cognition Disorders Psychology Neuroscience |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 20:158-162 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000087299 |
| Popis: | Corticobasal degeneration (CBD) is a rare disorder, which normally includes a combination of neurobehavioural features, movement disorders and other manifestations. It is now recognized that CBD patients usually present with two phenotypes: the lateralized phenotype and the dementia phenotype. The aim of our work was to determine the nature and the progression of cognitive and behavioural impairment in 10 lateralized CBD patients. In our patients, the most salient aspects of cognitive impairment were: an evident alteration of rapid alternating operative strategies, associated with the evident impairment of set shifting, of executive operations, of operative and sequential procedure and of implementation of judgement and abstract reasoning. The self-activation of retrieval processes is partly preserved in CBD. As all the other types of subcortical impairments, even CBD encompasses both cognitive impairment as well as a wide range of behaviour disturbances, such as progressive alterations of sleep, depression, and of anxiety (with a remarkable incidence of somatic pain). This suggests that in addition to neuropsychological assessment, quantification of the personality behaviour disorder is important for standardizing the diagnosis of subcortical vascular dementia and distinguishing it from any other dementias. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|