Sex differences in hepatic cytochrome P-450 monooxygenase activities in rainbow trout during an annual reproductive cycle
| Autor: | L. Förlin, C. Haux |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Cytochrome Trout Endocrinology Diabetes and Metabolism 7-Alkoxycoumarin O-Dealkylase Endocrinology Cytochrome P-450 Enzyme System Internal medicine medicine Animals Testosterone Benzopyrene Hydroxylase Sex Characteristics biology Estradiol Reproduction Body Weight Ethylmorphine-N-Demethylase Cytochrome P450 Organ Size Monooxygenase Sexual dimorphism Isoenzymes Liver Darkness biology.protein Microsome Rainbow trout Female Salmonidae |
| Zdroj: | The Journal of endocrinology. 124(2) |
| ISSN: | 0022-0795 |
| Popis: | Hepatic microsomal cytochrome P-450 monooxygenase activities were investigated in rainbow trout during an annual reproductive cycle. The fish were kept in tanks supplied with fresh water at a constant temperature of 10 °C. The daily light and darkness cycle was adjusted to follow the natural photoperiod. Sampling was performed once every month for 1 year. Higher benzo(a)pyrene-hydroxylase (or aryl hydrocarbon hydroxylase; AHH), ethoxycoumarin-O-deethylase (ECOD) and ethylmorphine-N-demethylase (END) activities and cytochrome P-450 content were found during the late stage of sexual development in rainbow trout. When monooxygenase activities were expressed on a per cytochrome P-450 basis, sex-dependent differences were observed only for AHH and ECOD activities. It was thus found that sex-dependent variations of END were closely correlated with the total amount of cytochrome P-450. The results indicate that differences exist in hepatic cytochrome P-450 isoenzyme patterns between the sexes in rainbow trout. The similarity of the annual pattern of plasma levels of oestradiol and testosterone to that of sex-dependent differences in the cytochrome P-450 monooxygenases support the contention that sex steroids play a role in regulating the cytochrome P-450 system. Journal of Endocrinology (1990) 124, 207–213 |
| Databáze: | OpenAIRE |
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