Effect of leukoreduction on transfusion-related immunomodulation in patients undergoing cardiac surgery
| Autor: | Neeti Makhija, Atif Irfan Khan, Ramakrishnan Lakshmy, Anjali Hazarika, Gopal Kumar Patidar, Sachin Talwar |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood transfusion Adolescent medicine.medical_treatment 030204 cardiovascular system & hematology Transfusion-related immunomodulation law.invention Immunomodulation 03 medical and health sciences 0302 clinical medicine law medicine Humans Leukapheresis Prospective Studies Cardiac Surgical Procedures Child Aged Aged 80 and over Postoperative Care Intraoperative Care business.industry Infant Transfusion medicine Hematology Middle Aged Intensive care unit Cardiac surgery Leukoreduction Anesthesia Child Preschool Female Fresh frozen plasma Packed red blood cells business Erythrocyte Transfusion 030215 immunology |
| Zdroj: | Transfusion medicine (Oxford, England)REFERENCES. 30(6) |
| ISSN: | 1365-3148 |
| Popis: | OBJECTIVES In this study, we aimed to determine the consequences of different amounts of leukocyte transfusion on the outcome of patients undergoing cardiac surgery. DESIGN This was a prospective, single-blinded cohort study conducted for 1 year from July 2018 to June 2019. SETTING The study setting was the Department of Transfusion Medicine, along with Cardiac Anaesthesia, Cardiac Surgery and Cardiac biochemistry departments in a tertiary care cardiac centre. PARTICIPANTS A total of 150 patients undergoing cardiac surgery during the study period were divided into three groups (50 in each): Leukofiltered (LR), Buffy coat depleted (BCD) and Non-leukoreduced (NLR). INTERVENTION The intervention was intra- and postoperative transfusion of packed red blood cells (PRBCs) having different amounts of leukocytes. MEASUREMENTS AND MAIN RESULTS Patient details about length of intensive care unit (ICU) and hospital stay, blood usage, inotropic drug duration, mechanical ventilation, urine output and infection were recorded from the patient data sheet, whereas patients were followed up for 30 days post-operation, and any mortality was noted. Haematological parameters and biochemical parameters for renal function test were analysed on pre- and post-surgical days 1, 3, 5 and 7, whereas on postoperative days 1 and 7, cytokine-like FAS ligands, Interleukin-10 (IL-10) and Interferon-γ (INF-γ) were tested. Patients in all three groups received an average of four, two and two units of packed red blood cells, platelets and fresh frozen plasma, respectively. There was a statistically significant (P |
| Databáze: | OpenAIRE |
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