Progressive regression of left ventricular hypertrophy two years after bariatric surgery
| Autor: | Susan T. Laing, Terry Scarborough, Anthony F. Boyer, Erik B. Wilson, Brad Snyder, Ursula G. Kyle, Carol Wolin-Riklin, Joshua G. Leichman, Charles C. Miller, Mohamed F. Algahim, Heinrich Taegtmeyer, Thomas R. Lux, Sherman Yu |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Time Factors Heart Ventricles Bariatric Surgery Left ventricular hypertrophy Ventricular Function Left Article Body Mass Index Insulin resistance Weight loss medicine Humans Resting energy expenditure Postoperative Period business.industry General Medicine Recovery of Function Middle Aged medicine.disease Prognosis Obesity Surgery Obesity Morbid Treatment Outcome Echocardiography Lean body mass Disease Progression Female Hypertrophy Left Ventricular medicine.symptom Weight Loss Surgery business Body mass index Follow-Up Studies |
| Zdroj: | The American journal of medicine. 123(6) |
| ISSN: | 1555-7162 |
| Popis: | Obesity is a systemic disorder associated with an increase in left ventricular mass and premature death and disability from cardiovascular disease. Although bariatric surgery reverses many of the hormonal and hemodynamic derangements, the long-term collective effects on body composition and left ventricular mass have not been considered before. We hypothesized that the decrease in fat mass and lean mass after weight loss surgery is associated with a decrease in left ventricular mass.Fifteen severely obese women (mean body mass index [BMI]: 46.7+/-1.7 kg/m(2)) with medically controlled hypertension underwent bariatric surgery. Left ventricular mass and plasma markers of systemic metabolism, together with body mass index (BMI), waist and hip circumferences, body composition (fat mass and lean mass), and resting energy expenditure were measured at 0, 3, 9, 12, and 24 months.Left ventricular mass continued to decrease linearly over the entire period of observation, while rates of weight loss, loss of lean mass, loss of fat mass, and resting energy expenditure all plateaued at 9 [corrected] months (P.001 for all). Parameters of systemic metabolism normalized by 9 months, and showed no further change at 24 months after surgery.Even though parameters of obesity, including BMI and body composition, plateau, the benefits of bariatric surgery on systemic metabolism and left ventricular mass are sustained. We propose that the progressive decrease of left ventricular mass after weight loss surgery is regulated by neurohumoral factors, and may contribute to improved long-term survival. |
| Databáze: | OpenAIRE |
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