Renal cell carcinoma in young compared to older patients: Comparison of clinicopathological risk factors and survival

Autor:	Jónas Magnússon, Vigdis Petursdottir, Sverrir Hardarson, Asgeir Thoroddsen, Eirikur Jonsson, Tomas Gudbjartsson, Gudmundur V. Einarsson
Rok vydání:	2008
Předmět:	Adult Male Oncology medicine.medical_specialty Prognostic variable Adolescent Urology Iceland Severity of Illness Index Risk Factors Renal cell carcinoma Internal medicine medicine Carcinoma Humans Risk factor Carcinoma Renal Cell Survival rate Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Age Factors Retrospective cohort study Middle Aged Prognosis medicine.disease Kidney Neoplasms Surgery Survival Rate Nephrology Female business Kidney cancer Follow-Up Studies Kidney disease
Zdroj:	Scandinavian Journal of Urology and Nephrology. 42:121-125
ISSN:	1651-2065 0036-5599
DOI:	10.1080/00365590701571555
Popis:	Renal cell carcinoma (RCC) is primarily a disease of the elderly, most patients being diagnosed in their mid-60s. However, a significant number of patients are diagnosed at a younger age. The true effect of age at diagnosis on survival has been debated, tumor stage and grade being the strongest prognostic factors of survival. The aim of this nationwide study was to study the significance of young age at diagnosis as a prognostic factor in RCC.This retrospective study included all living patients with histologically verified RCC in Iceland diagnosed between 1971 and 2000 (n = 629). Different clinicopathological factors of patients diagnosed aged50 years (n = 99) were compared to those of patients diagnosed agedor = 50 years (n = 530). Disease-specific survival was compared and multivariate analysis was used to evaluate prognostic variables.Clinical presentation, TNM stage, grade, tumor size and histological subtypes were comparable between the two groups. Prognostic factors were the same in both groups, most of them having a stronger prognostic value in younger patients. Both 5- and 10-year disease-specific survival was significantly higher in the younger group (66.4% vs 54.5% at 5 years).The clinicopathological profiles are comparable in RCC patients agedandor = 50 years. The reason for the more favorable survival of younger patients is not known. Further studies are needed, including studies on possible differences in age-specific host-tumor response.
Databáze:	OpenAIRE
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