Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease

Autor: Andrew M. Posselt, Marilyn McEnhill, Anthony A. Portale, K. A. Benedict, Stephen E. Gitelman, Peter G. Stock, S. Adi, J. L. Brennan, S. Moassesfar
Rok vydání: 2013
Předmět:
Nephrology
Blood Glucose
Male
Pediatrics
Kidney Disease
endocrine system diseases
medicine.medical_treatment
Medical and Health Sciences
Kidney Failure
renal disease
Immunology and Allergy
Pharmacology (medical)
Islet transplantation
type I diabetes
Chronic
Child
Kidney transplantation
Pediatric
geography.geographical_feature_category
Diabetes
Islet
Prognosis
Female
Pancreas Transplantation
Type 1
Adult
medicine.medical_specialty
Renal and urogenital
kidney transplantation
Pancreas transplantation
Autoimmune Disease
Article
End stage renal disease
Clinical Research
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Intensive care medicine
Metabolic and endocrine
Type 1 diabetes
geography
Transplantation
business.industry
Organ Transplantation
medicine.disease
Kidney Transplantation
Diabetes Mellitus
Type 1

Kidney Failure
Chronic

Surgery
business
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 13, iss 8
Popis: Islet transplantation after successful kidney transplantation is a recognized treatment for adults with diabetes and end-stage renal disease (ESRD), but has not been considered an option in the pediatric population. To our knowledge, we report the first combined islet and kidney transplant in a child. The patient was born with bilateral renal hypoplasia and was diagnosed with type 1 diabetes mellitus at age 13 months. He had erratic glycemic control and hypoglycemia unawareness. At 6 years of age, the child safely underwent simultaneous islet and live donor kidney transplantation. Although function of the islet graft was transient, the combined transplant provided significant benefits in terms of glucose control and overall growth and development. Such an approach represents a viable treatment option for pediatric patients with ESRD and unstable diabetes.
Databáze: OpenAIRE