Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease
Autor: | Andrew M. Posselt, Marilyn McEnhill, Anthony A. Portale, K. A. Benedict, Stephen E. Gitelman, Peter G. Stock, S. Adi, J. L. Brennan, S. Moassesfar |
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Rok vydání: | 2013 |
Předmět: |
Nephrology
Blood Glucose Male Pediatrics Kidney Disease endocrine system diseases medicine.medical_treatment Medical and Health Sciences Kidney Failure renal disease Immunology and Allergy Pharmacology (medical) Islet transplantation type I diabetes Chronic Child Kidney transplantation Pediatric geography.geographical_feature_category Diabetes Islet Prognosis Female Pancreas Transplantation Type 1 Adult medicine.medical_specialty Renal and urogenital kidney transplantation Pancreas transplantation Autoimmune Disease Article End stage renal disease Clinical Research Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans Intensive care medicine Metabolic and endocrine Type 1 diabetes geography Transplantation business.industry Organ Transplantation medicine.disease Kidney Transplantation Diabetes Mellitus Type 1 Kidney Failure Chronic Surgery business |
Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 13, iss 8 |
Popis: | Islet transplantation after successful kidney transplantation is a recognized treatment for adults with diabetes and end-stage renal disease (ESRD), but has not been considered an option in the pediatric population. To our knowledge, we report the first combined islet and kidney transplant in a child. The patient was born with bilateral renal hypoplasia and was diagnosed with type 1 diabetes mellitus at age 13 months. He had erratic glycemic control and hypoglycemia unawareness. At 6 years of age, the child safely underwent simultaneous islet and live donor kidney transplantation. Although function of the islet graft was transient, the combined transplant provided significant benefits in terms of glucose control and overall growth and development. Such an approach represents a viable treatment option for pediatric patients with ESRD and unstable diabetes. |
Databáze: | OpenAIRE |
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