In vivo canine study of three different coatings applied to p64 flow-diverter stents: initial biocompatibility study
| Autor: | Adnan H. Siddiqui, Ralf Hannes, Hermann Monstadt, Pervinder Bhogal, Pedro Lylyk, Tim Lenz-Habijan, Rosa Martinez Moreno, Hans Henkes, Catrin Bannewitz |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty lcsh:R895-920 medicine.medical_treatment External carotid artery Medizin Fibrin 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.artery medicine Radiology Nuclear Medicine and imaging cardiovascular diseases Biocompatible materials Thrombus Disease models (animal) medicine.diagnostic_test biology business.industry Stent Interventional radiology Intracranial aneurysm Clopidogrel medicine.disease Surgery Surface coating Angiography biology.protein Original Article Stents business 030217 neurology & neurosurgery Materials testing medicine.drug |
| Zdroj: | European Radiology Experimental European Radiology Experimental, Vol 3, Iss 1, Pp 1-13 (2019) |
| ISSN: | 2509-9280 |
| Popis: | BACKGROUND: Flow-diverter stents (FDSs) have revolutionised the treatment of intracranial aneurysms. However, associated dual antiplatelet treatment is mandatory. We investigated the biocompatibility of three proprietary antithrombogenic coatings applied to FDSs. METHODS: After Institutional Animal Care and Use Committee approval, four domestic juvenile female dogs (weight 19.9 ± 0.9 kg, mean ± standard deviation) were commenced on three different oral antiplatelet regimes: no medication (n = 1), acetylsalicylic acid (n = 2), and acetylsalicylic acid and clopidogrel (n = 1). Four p64 FDSs were randomly implanted into the subclavian, common carotid, and external carotid arteries of each dog, including both uncoated p64 stents and p64 stents coated with three different antithrombogenic hydrophilic coating (HPC). Angiography and histological examinations were performed. Wilcoxon/Kruskal-Wallis and ANOVA were used with p value |
| Databáze: | OpenAIRE |
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