Mortality and microbial diversity after allogenic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
| Autor: | Ingebjørg Seljeflot, Johannes R. Hov, Vemund Paulsen, Asta Bye, Geir E. Tjønnfjord, Kristin Aneta Joan Skaarud, Knut E.A. Lundin, Per Ole Iversen, Marius Trøseid, Simen Hyll Hansen, Jørgen Valeur, Martin Kummen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Microbial diversity medicine.medical_treatment Science Physiology Hematopoietic stem cell transplantation Stem cells Gut flora Article 03 medical and health sciences Feces Young Adult Nutritional intervention trials 0302 clinical medicine Medical research Secondary analysis Medicine Humans Transplantation Homologous Mortality Transplantation Multidisciplinary biology business.industry Nutritional Support Hematopoietic Stem Cell Transplantation Middle Aged biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology 030220 oncology & carcinogenesis Female Microbial diversities Stem cell business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Gut mucosal barrier injury is common following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and associated with poor clinical outcomes. Diet is critical for microbial diversity, but whether nutritional support affects microbiota and outcome after allo-HSCT is unknown. We present a secondary analysis of a randomized controlled nutritional intervention trial during allo-HSCT. We investigated if the intervention influenced gut microbiota, short-chain fatty acids (SCFAs), and markers of gut barrier functions, and if these parameters were associated with clinical outcomes. Fecal specimens were available from 47 recipients, and subjected to 16S rRNA gene sequencing. We found no significant differences between the intervention group and controls in investigated parameters. We observed a major depletion of microbiota, SCFAs, and altered markers of gut barrier function from baseline to 3 weeks post-transplant. One-year mortality was significantly higher in patients with lower diversity at 3 weeks post-HSCT, but not related to diversity at baseline. The relative abundance of Blautia genus at 3 weeks was higher in survivors. Fecal propionic acid was associated with survival. Markers of gut barrier functions were less strongly associated with clinical outcomes. Possibly, other strategies than dietary intervention are needed to prevent negative effects of gut microbiota and clinical outcomes after allo-HSCT. The study was supported by Oslo University Hospital, Larvik Cancer Society, Norwegian Nurses Organization and the Throne Holst Foundation, Norway. The tube feeding was provided by Nutricia, Norway. |
| Databáze: | OpenAIRE |
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