Forces directing germ-band extension in Drosophila embryos
| Autor: | Jörg Großhans, Deqing Kong, Fred Wolf |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Embryology Embryo Nonmammalian Embryonic Development Biology 03 medical and health sciences Extension (metaphysics) medicine Directionality Animals Drosophila Proteins Calcium Signaling Process (anatomy) Body Patterning Polarity (international relations) Models Statistical Germ-band extension Convergent extension Gene Expression Regulation Developmental Epithelial Cells Anatomy Cadherins Embryonic stem cell Actins Cell biology Biomechanical Phenomena 030104 developmental biology medicine.anatomical_structure Drosophila melanogaster Epidermal Cells Endoderm Epidermis Cell Division Developmental Biology |
| Zdroj: | Mechanisms of Development |
| Popis: | Body axis elongation by convergent extension is a conserved developmental process found in all metazoans. Drosophila embryonic germ-band extension is an important morphogenetic process during embryogenesis, by which the length of the germ-band is more than doubled along the anterior-posterior axis. This lengthening is achieved by typical convergent extension, i.e. narrowing the lateral epidermis along the dorsal-ventral axis and simultaneous extension along the anterior-posterior axis. Germ-band extension is largely driven by cell intercalation, whose directionality is determined by the planar polarity of the tissue and ultimately by the anterior-posterior patterning system. In addition, extrinsic tensile forces originating from the invaginating endoderm induce cell shape changes, which transiently contribute to germ-band extension. Here, we review recent progress in understanding of the role of mechanical forces in germ-band extension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|