Targeting Rho GTPase signaling for cancer therapy
| Autor: | Michael F. Olson, Katerina Mardilovich, Mark Baugh |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
rho GTP-Binding Proteins
Cancer Research Cancer therapy Antineoplastic Agents GTPase Biology Protein Serine-Threonine Kinases Neoplasms medicine Animals Guanine Nucleotide Exchange Factors Humans Molecular Targeted Therapy Pharmaceutical sciences Enzyme Inhibitors Cytoskeleton rho-Associated Kinases Effector Kinase Rho GTPases Cancer Lim Kinases General Medicine medicine.disease Cell biology Enzyme Activation Oncology p21-Activated Kinases Signal transduction Protein Processing Post-Translational Signal Transduction |
| Zdroj: | Future oncology (London, England). 8(2) |
| ISSN: | 1744-8301 |
| Popis: | Accumulating evidence from basic and clinical studies supports the concept that signaling pathways downstream of Rho GTPases play important roles in tumor development and progression. As a result, there has been considerable interest in the possibility that specific proteins in these signal transduction pathways could be potential targets for cancer therapy. A number of inhibitors targeting critical effector proteins, activators or the Rho GTPases themselves, have been developed. We will review the strategies currently being used to develop inhibitors of Rho GTPases and downstream signaling kinases and discuss candidate entities. Although molecularly targeted drugs that inhibit Rho GTPase signaling have not yet been widely adopted for clinical use, their potential value as cancer therapeutics continues to drive considerable pharmaceutical research and development. |
| Databáze: | OpenAIRE |
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