| Autor: |
Solleder, M., Racle, J., Guillaume, P., Coukos, G., Bassani-Sternberg, M., Gfeller, D. |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
iScience, vol. 25, no. 5, pp. 104215 |
| ISSN: |
2589-0042 |
| Popis: |
CD4 + T cell activation in infectious diseases and cancer is governed by the recognition of peptides presented on class II human leukocyte antigen (HLA-II) molecules. Therefore, HLA-II ligands represent promising targets for vaccine design and personalized cancer immunotherapy. Much work has been done to identify and predict unmodified peptides presented on HLA-II molecules. However, little is known about the presentation of phosphorylated HLA-II ligands. Here, we analyzed Mass Spectrometry HLA-II peptidomics data and identified 1,943 unique phosphorylated HLA-II ligands. This enabled us to precisely define phosphorylated binding motifs for more than 30 common HLA-II alleles and to explore various molecular properties of phosphorylated peptides. Our data were further used to develop the first predictor of phosphorylated peptide presentation on HLA-II molecules. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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