Perflubron emulsion (AF0144) augments harvesting of autologous blood: A phase II study in cardiac surgery
| Autor: | N. Simon Faithfull, Steven E. Hill, Bruce J. Leone, Peter E. Keipert, Mark F. Newman, Kathy E. Flaim |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Hematocrit law.invention chemistry.chemical_compound law Internal medicine Cardiopulmonary bypass medicine Humans Blood Transfusion Single-Blind Method Coronary Artery Bypass Adverse effect Aged Fluorocarbons Hemodilution Cardiopulmonary Bypass Hematology medicine.diagnostic_test Perflubron business.industry Middle Aged Hydrocarbons Brominated Surgery Cardiac surgery Anesthesiology and Pain Medicine medicine.anatomical_structure chemistry Blood chemistry Anesthesia Female Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 16:555-560 |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/jcan.2002.126947 |
| Popis: | Objective: To assess tolerance and preliminary efficacy of a perfluorocarbon emulsion (AF0144) used with acute normovolemic hemodilution to reduce allogeneic blood transfusion for patients undergoing coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB). Design: Controlled, single-blind, parallel-group phase II dose escalation trial. Setting: Single-institution university medical center. Participants: Adult patients undergoing elective CABG surgery (n = 36). Interventions: A calculated volume of autologous whole blood was harvested for each patient with a target on-bypass hematocrit of 20% to 22%. Placebo, low-dose (1.8 g/kg) AF0144, or high-dose (2.7 g/kg) AF0144 was infused. During CPB, blood was transfused at protocol-defined triggers (hematocrit |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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