The Nuclear Lamina: Protein Accumulation and Disease
Autor: | Troy A. A. Harkness, Joanna M. Bridger, Zoe E. Gillespie, Christopher H. Eskiw, Valeria Martinez, Carla Almendáriz-Palacios, Matthew Janzen, Darrell D. Mousseau |
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Rok vydání: | 2020 |
Předmět: |
Premature aging
lamina autophagy DNA repair premature aging Neurodegeneration neurodegeneration Medicine (miscellaneous) Review clearance Biology Protein aggregation medicine.disease General Biochemistry Genetics and Molecular Biology Cell biology protein accumulation Proteostasis lcsh:Biology (General) Protein biosynthesis medicine Nuclear lamina Epigenetics lcsh:QH301-705.5 |
Zdroj: | Biomedicines Biomedicines, Vol 8, Iss 188, p 188 (2020) |
ISSN: | 2227-9059 |
Popis: | Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging. One proteinaceous structure underlying the nuclear envelope—the nuclear lamina—coordinates essential processes including DNA repair, genome organization and epigenetic and transcriptional regulation. Loss of proteostasis within the nuclear lamina results in the accumulation of proteins, disrupting these essential functions, either via direct interactions of protein aggregates within the lamina or by altering systems that maintain lamina structure. Here we discuss the links between proteostasis and disease of the nuclear lamina, as well as how manipulating specific proteostatic pathways involved in protein clearance could improve cellular health and prevent/reverse disease. |
Databáze: | OpenAIRE |
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