Measurement of squamous cell carcinoma antigen 2 in lichen planus patients
| Autor: | Mai A. Samir, Fathia M Khattab |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Youden's J statistic Mucocutaneous zone Dermatology Squamous cell carcinoma Antigen Gastroenterology Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Antigens Neoplasm Internal medicine Psoriasis medicine Humans Serpins Tumor marker business.industry Therapeutic effect Lichen Planus medicine.disease Blockade 030220 oncology & carcinogenesis Female business |
| Zdroj: | Journal of Cosmetic Dermatology. 19:1780-1784 |
| ISSN: | 1473-2165 1473-2130 |
| DOI: | 10.1111/jocd.13216 |
| Popis: | BACKGROUND Lichen planus (LP) is an autoinflammatory mucocutaneous skin disorder with a multifactorial pathogenesis. Squamous cell carcinoma antigen (SCCA) is a tumor marker recognized as a part of the ovalbumin-serpin family. In patients' serum and skin, SCCA expression is increased with inflammatory skin diseases as psoriasis. AIM This study aimed to estimate serum SCCA2 levels in patients with LP and to assess its relationship with disease severity and types. PATIENTS AND METHODS We included 34 adult patients with LP and 20 healthy adults as control. The total score of LP activity, area, and severity index was calculated for all patients, whereas serum SCCA2 levels were measured in all participants using enzyme-linked immunosorbent assay. RESULTS The mean serum SCCA2 levels were significantly higher in patients than their healthy controls (P |
| Databáze: | OpenAIRE |
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