Analysis of positional isomers of 2-3-4-alkoxyphenylcarbamic acid derivatives by a combination of TLC and IMS
| Autor: | Bartosz Michalczuk, Štefan Matejčík, Zuzana Štiffelová, Fils Andriamainty, Jozef Čižmárik, Ladislav Moravský |
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| Rok vydání: | 2020 |
| Předmět: |
Chromatography
Ion-mobility spectrometry Chemistry 010401 analytical chemistry Clinical Biochemistry Phenylcarbamates Cell Biology General Medicine 010501 environmental sciences 01 natural sciences Biochemistry Thin-layer chromatography Combined approach 0104 chemical sciences Analytical Chemistry Ion Isomerism Desorption Ion Mobility Spectrometry Alkoxy group Structural isomer Chromatography Thin Layer Volatility (chemistry) 0105 earth and related environmental sciences |
| Zdroj: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1184 |
| ISSN: | 1873-376X |
| Popis: | In this study, we have demonstrated a separation of positional isomers of some derivatives of alkoxyphenylcarbamic acid. These compounds belong to drugs with local anesthetics activity. The low volatility compounds were analysed by a Thin Layer Chromatography (TLC) and Ion Mobility Spectrometry (IMS) using diode laser desorption for sample introduction to IMS. This combined approach allowed the identification of compounds. Also, we have carried out IMS studies of all compounds and determined their ion mobilities The ion mobilities were increasing with the geometry change from position ortho to para of alkoxy chain, which is in agreement with their different collision cross section (CCS). |
| Databáze: | OpenAIRE |
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