Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

Autor: Guillermo Barturen, Elena Carnero-Montoro, Manuel Martínez-Bueno, Silvia Rojo-Rello, Beatriz Sobrino, Óscar Porras-Perales, Clara Alcántara-Domínguez, David Bernardo, Marta E. Alarcón-Riquelme
Přispěvatelé: Junta de Andalucía, European Commission, Consejo Superior de Investigaciones Científicas (España), Junta de Castilla y León, Instituto de Salud Carlos III
Rok vydání: 2021
Předmět:
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
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ISSN: 2041-1723
Popis: SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNAmethylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression andmediated by genetic loci.We find an environmental trait-related signature that discriminatesmild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.
Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades of the regional government of Andalucia
European Union through European Regional Development Fund CV20-10150
Consejo Superior de Investigaciones cientificas CSIC-COV19-016/202020E155
Junta de Castilla y Leon COVID 07.04.467B04.74011.0
Consejeria de Salud y Familias of the regional government of Andalucia PECOVID-0072-2020
Instituto de Salud Carlos III (ISCIII, Spanish Health Ministry) through the Sara Borrell subprogram CD18/00153
Programa Estrategico Instituto de Biologia y Genetica Molecular, IBGM excellence programme CLU-2029-02 CCVC8485
Databáze: OpenAIRE
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