Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer
| Autor: | Nan Chen, Juan Wang, Yi-feng Liao, Huitao Zhang, Hongyu Zhang, Hongtao Chen, Tianze Liu |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty In situ hybridization Kaplan-Meier Estimate Biology Malignancy Disease-Free Survival Internal medicine Carcinoma Non-Small-Cell Lung medicine Carcinoma Biomarkers Tumor Tensin PTEN Humans Clinical significance Lung cancer In Situ Hybridization Aged Neoplasm Staging Aged 80 and over PTEN Phosphohydrolase General Medicine Middle Aged medicine.disease Prognosis Gene Expression Regulation Neoplastic MicroRNAs Lymphatic Metastasis biology.protein Immunohistochemistry Female |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(9) |
| ISSN: | 1423-0380 |
| Popis: | The aim of this study was to explore the expression and clinical significance of miR-494 and PTEN (phosphatase and tensin homologue deleted on chromosome ten) in non-small cell lung cancer (NSCLC). Immunohistochemistry for PTEN and in situ hybridization (ISH) for miR-494 were performed in 92 NSCLC tissues and 10 normal lung tissues to detect their expression, and correlation between their expression with clinical characteristics and prognosis was analyzed. The expression of miR-494 was significantly higher in NSCLC than in normal lung tissues (P = 0.004). The positive expression of PTEN protein in the lung carcinoma tissues was significantly lower than that in the normal lung tissues (P = 0.013), while the level of miR-494 expression was negatively correlated with PTEN expression (r = −0.577, P |
| Databáze: | OpenAIRE |
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