Fat distribution influences the cardio-metabolic profile in a clinically healthy European population

Autor: Zoltan Pataky, M. Kozakova, Alain Golay, Elisabetta Bobbioni-Harsch, Vincent Makoundou, J. Dekker
Přispěvatelé: EMGO - Lifestyle, overweight and diabetes
Rok vydání: 2009
Předmět:
Male
medicine.medical_treatment
Clinical Biochemistry
Lipids/*blood
Adipose tissue
Glucose/*metabolism
Biochemistry
chemistry.chemical_compound
Waist–hip ratio
Heart Rate
Blood plasma
Insulin
Ultrasonography
C-Peptide
Tunica Intima/ultrasonography
General Medicine
Middle Aged
Lipids
Triglycerides/blood
Cholesterol
Carotid Artery
Common/physiopathology/*ultrasonography
C-Peptide/blood
Female
Tunica Media/ultrasonography
Waist Circumference
Tunica Media
Adult
medicine.medical_specialty
ddc:174.957
Waist
Carotid Artery
Common
European Continental Ancestry Group
Cholesterol/blood
White People
Insulin resistance
Internal medicine
Heart rate
medicine
Humans
Triglycerides
Waist-Hip Ratio
business.industry
medicine.disease
Glucose
Endocrinology
chemistry
Waist Circumference/*physiology
Insulin Resistance
Tunica Intima
Insulin/blood
business
Zdroj: European Journal of Clinical Investigation, 39(12), 1055-1064
Bobbioni-Harsch, E, Pataky, Z, Makoundou, V, Kozakova, M, Dekker, J & Golay, A 2009, ' Fat distribution influences the cardio-metabolic profile in a clinically healthy European population ', European Journal of Clinical Investigation, vol. 39, no. 12, pp. 1055-1064 . https://doi.org/10.1111/j.1365-2362.2009.02211.x
European Journal of Clinical Investigation, Vol. 39, No 12 (2009) pp. 1055-1064
ISSN: 1365-2362
0014-2972
DOI: 10.1111/j.1365-2362.2009.02211.x
Popis: BACKGROUND AND AIMS: Waist and hip circumferences are largely influenced by Fat Mass and several other determinants. To evaluate the specific effects of a preferential fat distribution, we corrected the waist and hip circumferences for all their determinants. We then examined the association between fat distribution and several cardio-metabolic parameters in a clinically healthy population. SUBJECTS AND METHODS: In a subgroup of 625 females (F) and 490 males (M) from the RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) study, we evaluated insulin sensitivity by hyperinsulinaemic euglycaemic clamp and intima-media thickness (IMT) of the common (CCA) and internal (ICA) carotid artery by ultrasound imaging. Waist and hip circumferences were adjusted for age, height, fat and fat-free mass; in males, waist was also adjusted by hip and vice versa. RESULTS: Both F and M with enlarged waist showed significantly increased plasma insulin, C-peptide, total cholesterol, non-high density lipoprotein-cholesterol, low density lipoprotein cholesterol and triglycerides, when compared with subjects with a smaller waist circumference. Males also showed lower glucose uptake and higher heart rate and ICA-IMT. A larger hip in both females and males was linked to a significantly greater inhibition of free fatty acids during the clamp test. CONCLUSION: Adjustment of waist circumference for its determinants permits the detection of early impairment of cardiovascular function and of glucose and lipid metabolism in a clinically healthy population, in particular in normal body weight subjects. Enlarged hip adjusted values are associated with greater insulin sensitivity.
Databáze: OpenAIRE
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