Comparison between 24‐h proteinuria, urinary protein/creatinine ratio and dipstick test in patients with nephropathy: Patterns of proteinuria in dipstick‐negative patients

Autor:	S Masini, D Motta, Massimo Gai, Sara Giunti, Giacomo Lanfranco, Elisabetta Mezza, Giuseppe Paolo Segoloni, Fabrizio Fop
Rok vydání:	2006
Předmět:	Adult Immunofixation Urinary protein medicine.medical_specialty Time Factors Adolescent Urinary system Clinical Biochemistry Urology urologic and male genital diseases Dipstick test Nephropathy chemistry.chemical_compound Reference Values Internal medicine Linear regression medicine Humans Aged Reagent Strips Aged 80 and over Creatinine Proteinuria biology business.industry General Medicine Dipstick Middle Aged Urinary protein/creatinine ratio medicine.disease 24-h proteinuria Endocrinology ROC Curve chemistry Laboratory methods Linear Models biology.protein Kidney Diseases medicine.symptom business
Zdroj:	Scandinavian Journal of Clinical and Laboratory Investigation. 66:299-308
ISSN:	1502-7686 0036-5513
DOI:	10.1080/00365510600608563
Popis:	Three main tests are commonly employed for the measurement of proteinuria: the dipstick test, the urinary protein/creatinine ratio (P/C) and the 24-h urine collection. The aim of this study was to evaluate the correlation between these methods, comparing linear regression and ROC curve data.A total of 297 consecutive outpatients with different renal diseases were included in the study. Twenty-four-hour proteinuria was considered the reference test.A high degree of correlation was observed between all the tests (p0.0001), the highest regression coefficient being between 24-h proteinuria and P/C (R=0.82), and the lowest between P/C and the dipstick test (R=0.72). The dipstick test failed to detect pathological proteinuria in 94 patients (31.6%). Therefore, in these subjects, the patterns of proteinuria were assessed by immunofixation and sodium dodecyl sulphate (SDS) electrophoresis.Our data strongly support the use of urinary P/C for the detection of proteinuria, at least in nephrology units, where the prevalence of proteinuria is likely to be high.
Databáze:	OpenAIRE
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