Effects of Monosodium Glutamate-Induced Obesity in Spontaneously Hypertensive Rats vs. Wistar Kyoto Rats: Serum Leptin and Blood Flow to Brown Adipose Tissue
| Autor: | Noriyasu Shinohara, Masatoshi Fujishima, Kenzo Iino, Mototaka Yoshinari, Kenji Tashiro, Kojiro Ichikawa, Masanori Iwase, Setsuro Ibayashi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Leptin
Male medicine.medical_specialty Physiology Monosodium glutamate Adipose tissue Adrenergic beta-3 Receptor Agonists Blood Pressure Rats Inbred WKY chemistry.chemical_compound Adipose Tissue Brown Weight loss Rats Inbred SHR Internal medicine Sodium Glutamate Weight Loss Brown adipose tissue Ketogenesis Internal Medicine medicine Animals Obesity business.industry Hypertriglyceridemia Adrenergic beta-Agonists medicine.disease Rats Disease Models Animal Blood pressure medicine.anatomical_structure Endocrinology chemistry Ethanolamines Regional Blood Flow Hypertension cardiovascular system Female Food Additives medicine.symptom Energy Intake Cardiology and Cardiovascular Medicine business |
| Zdroj: | Hypertension Research. 23:503-510 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1291/hypres.23.503 |
| Popis: | We compared the effects of hypothalamic obesity induced by neonatal monosodium glutamate (MSG) treatment between spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Newborn WKY and SHR were injected intraperitoneally with 4 mg/kg body weight of MSG daily for 5 days. At 6 months of age, the obesity of SHR was more advanced than that of WKY, but at 14 months of age the severity of obesity was similar between the two strains. Hypertriglyceridemia was enhanced in MSG-treated SHR as compared with MSG-treated WKY. Systolic blood pressure measured by the tail-cuff method was consistently lower in MSG-treated SHR than in control SHR, whereas blood pressure was not affected by neonatal MSG treatment in WKY. Food restriction reduced body weight more in control SHR than in control WKY, with the former also showing enhanced ketogenesis. Neonatal MSG treatment abolished the accelerated reduction of body weight in SHR. Serum leptin concentration was markedly increased in MSG-treated obese rats, though no differences were seen between WKY and SHR in the control or MSG-treated groups. Serum leptin was closely correlated with both Lee obese index and mesenteric fat weight over the strain. Blood flow in interscapular brown adipose tissue (BAT) measured by Laser Doppler flowmetry was significantly increased in response to beta3-adrenoceptor agonist BRL26830A in both the control and MSG-treated rats. However, the response of blood flow was not affected by MSG treatment or strain difference. The present study demonstrated some strain differences in response to neonatal MSG treatment between WKY and SHR. These differences could not be explained by the difference in serum leptin level or beta3-adrenergic reactivity in BAT. |
| Databáze: | OpenAIRE |
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