Particulate air pollution and vascular reactivity: the bus stop study
| Autor: | Mary M. Dalipaj, Terrence D. Ruddy, Ling Liu, Ryan Kulka, Jeff B. Willey, Mietek Szyszkowicz, Robert Dales |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urban Population Vasodilation chemistry.chemical_compound medicine.artery Internal medicine medicine Humans Nitrogen dioxide Brachial artery Ontario business.industry Public Health Environmental and Occupational Health Particulates Middle Aged Particulate air pollution Surgery Motor Vehicles medicine.anatomical_structure chemistry Cardiology Blood Vessels Female Particulate Matter business Endothelin receptor Blood vessel Artery |
| Zdroj: | International archives of occupational and environmental health. 81(2) |
| ISSN: | 0340-0131 |
| Popis: | Particulate air pollution is associated with cardiovascular morbidity but mechanisms are not well understood. We tested the effects on vascular reactivity of exposure to fine particulates matter mass (PM(2.5)), number of particlesor=1 microm/m(3) (PM(1.0)) and nitrogen dioxide concentration (NO(2)).About 39 healthy volunteers sat outside for 2 h at two different Ottawa bus stops. Flow-mediated vasodilation (FMD) of the brachial artery was then measured by ultrasound and expressed as: (maximum artery diameter after release of a blood pressure cuff inflated above systolic pressure-baseline resting diameter)/baseline resting diameter.A 30 microg/m(3) increase in PM(2.5) exposure corresponded to a 0.48% reduction in FMD, P=0.05 representing a 5% relative change in the maximum ability to dilate. Results were consistent between the two bus stops and not sensitive to type of analysis. No significant association was found between FMD and NO(2), PM(1.0) or traffic density.PM(2.5) may reduce the capacity to vasodilate, a potential explanation for the documented association with cardiovascular morbidity. |
| Databáze: | OpenAIRE |
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