A multicenter study of neurocognition in children with hypertension: Methods, challenges, and solutions
| Autor: | Marc B. Lande, Stephen R. Hooper, Donald L. Batisky, Peter G. Szilagyi, Heather R. Adams, Juan C. Kupferman |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Neurocognitive testing medicine.medical_specialty Adolescent Neuropsychological Tests Article Executive Function Cognition Study methods Internal Medicine medicine Humans Prospective Studies Child Intensive care medicine Psychiatry business.industry Target organ damage Clinical research Blood pressure Multicenter study Research Design Hypertension Female Essential Hypertension Cognition Disorders Cardiology and Cardiovascular Medicine business Neurocognitive |
| Zdroj: | Journal of the American Society of Hypertension. 7:353-362 |
| ISSN: | 1933-1711 |
| DOI: | 10.1016/j.jash.2013.05.003 |
| Popis: | Hypertensive adults demonstrate decreased performance on neurocognitive testing compared with that of normotensive controls. There is now emerging, preliminary evidence that children with hypertension also manifest neurocognitive differences when compared with normotensive controls, findings postulated to potentially represent early signs of hypertensive target organ damage to the brain. However, reports in children to date have been limited to database and single-center studies. We have established an ongoing, prospective, multicenter study of neurocognition in children with primary hypertension. This article outlines the study methods, with particular attention to the unique challenges in this area of clinical research. We highlight aspects of the study design that are specifically designed as solutions to these challenges. |
| Databáze: | OpenAIRE |
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