Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct
| Autor: | Savas Baris, Esra Aciman, Ahmet Dursun, Görkem Mungan, Handan Ankarali, Vildan Sumbuloglu, Sureyya Ekem, Feryal Cabuk, Nida Tascilar, Sevcan Tug Bozdogan |
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| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2008 |
| Předmět: |
Apolipoprotein E
Adult Male medicine.medical_specialty Turkish population Apolipoprotein B Genotype Lipoproteins Apolipoprotein E4 Apolipoprotein E3 Risk Factors Diabetes mellitus Internal medicine Medicine Humans Genetic Predisposition to Disease Allele Stroke Apolipoproteins A Aged Apolipoproteins B Aged 80 and over Polymorphism Genetic biology business.industry Lipoprotein(a) Cerebral Infarction Cholesterol LDL Middle Aged medicine.disease Atherosclerosis Apolipoprotein E polymorphism Lipids Endocrinology Neurology biology.protein lipids (amino acids peptides and proteins) Female Neurology (clinical) business Apolipoprotein A Lipoprotein |
| Zdroj: | Journal of the neurological sciences. 277(1-2) |
| ISSN: | 0022-510X |
| Popis: | Background and purpose: Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known. The roles of apoE polymorphism and of high Lp(a) levels in atherosclerotic stroke (AS) in the Turkish population are unclear. Our aim was to investigate the relationship of apoE alleles and Lp(a) level with AS and the relationship of apoE alleles with Lp(a) and other lipid parameters. Methods: ApoE polymorphisms and lipid parameters were prospectively evaluated in 85 patients and 77 controls with normal brain imaging. Results: Only hypertension, diabetes mellitus, associated vascular diseases and decreased high-density lipoprotein cholesterol levels were found to be independent risk factors for stroke. However, in the presence of apoE/E4 allele, increased low-density lipoprotein cholesterol (LDL-chol), apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only Lp(a) levels were determined as risk factors. Conclusion: This study showed that while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors in E3 or E4 carriers. © 2008 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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