Prevalence and Outcomes of Hepatitis B Coinfection and Associated Liver Disease Among Antiretroviral Therapy-Naive Individuals in a Rural Tanzanian Human Immunodeficiency Virus Cohort
| Autor: | Ramírez-Mena, Adrià, Glass, Tracy R., Winter, Annja, Kimera, Namvua, Ntamatungiro, Alex J., Hatz, Christoph, Tanner, Marcel, Battegay, Manuel, Furrer, Hansjakob, Wandeler, Gilles, Letang, Emilio, KIULARCO Study Group |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Hepatitis B virus
HBsAg medicine.medical_specialty Cirrhosis 610 Medicine & health medicine.disease_cause Tanzania Gastroenterology Major Articles 03 medical and health sciences Liver disease 0302 clinical medicine 360 Social problems & social services Internal medicine VIH (Virus) Medicine 030212 general & internal medicine Prospective cohort study APRI liver fibrosis HIV (Viruses) business.industry Virus de l'hepatitis B HIV virus diseases Hepatitis B Tanzània medicine.disease 3. Good health Infectious Diseases Oncology Cohort Immunology Coinfection 030211 gastroenterology & hepatology business hepatitis B virus |
| Zdroj: | Ramírez-Mena, Adrià; Glass, Tracy R.; Winter, Annja; Kimera, Namvua; Ntamatungiro, Alex; Hatz, Christoph; Tanner, Marcel; Battegay, Manuel; Furrer, Hansjakob; Wandeler, Gilles; Letang, Emilio (2016). Prevalence and Outcomes of Hepatitis B Coinfection and Associated Liver Disease Among Antiretroviral Therapy-Naive Individuals in a Rural Tanzanian Human Immunodeficiency Virus Cohort. Open Forum Infectious Diseases, 3(3), ofw162. Oxford University Press 10.1093/ofid/ofw162 Open Forum Infectious Diseases Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofw162 |
| Popis: | Key findings include a high prevalence of APRI score indicating significant fibrosis/cirrhosis in ART-naïve individuals particularly among HIV/HBV-co-infected individuals and a regression of APRI to Background. We evaluated the prevalence of chronic hepatitis B virus (HBV) infection and liver fibrosis/cirrhosis in human immunodeficiency virus (HIV)-infected individuals enrolled in a rural Tanzanian prospective cohort and assessed hepatic fibrosis progression 12–24 months after antiretroviral treatment (ART) initiation. Methods. All ART-naive HIV-infected adults ≥15-year-old enrolled in the Kilombero and Ulanga Antiretroviral Cohort who started ART between 2005 and 2015 were included. Pre-ART factors associated with significant liver fibrosis (aspartate aminotransferase-to-platelet ratio index [APRI] >1.5) and cirrhosis (APRI > 2.0) were identified using logistic regression. Results. Of 3097 individuals screened, 227 (7.3%; 95% CI, 6.4–8.2) were hepatitis B surface antigen (HBsAg) positive. Before ART initiation, 9.1% individuals had significant liver fibrosis and 5.3% had cirrhosis. Human immunodeficiency virus/HBV-coinfected individuals were more likely to have an APRI score indicating significant fibrosis (14.2% vs 8.7%, P = .03) and cirrhosis (9.2% vs 4.9%, P = .03) than HBV-uninfected patients. CD4 cell count |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|