Value of baseline serum thyrotropin as a predictor of hypothyroidism in patients with diabetes mellitus
| Autor: | Raghu Kadiyala, Faisal Fayyaz, Piero Baglioni, Onyebuchi E. Okosieme, Akhila Mallipedhi, Vijay Ramasamy |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Thyrotropin Reference range Type 2 diabetes Endocrinology Hypothyroidism Internal medicine Diabetes mellitus medicine Humans Survival analysis Subclinical infection Aged Retrospective Studies business.industry General Medicine Middle Aged medicine.disease Confidence interval Thyroxine Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Relative risk Thyrotropin Measurement Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 17(1) |
| ISSN: | 1934-2403 |
| Popis: | Objective: To determine whether serum thyrotropin measurement performed at diagnosis of diabetes mellitus or at initial patient contact predicts subsequent development of hypothyroidism. Methods: We retrospectively reviewed the computerized records of patients attending annual visits between January 2008 and December 2008 at a hospital diabetes mellitus clinic. Serum free thyroxine and thyrotropin at current and baseline annual visits were documented. A Cox regression model was used to analyze the relationship between development of thyroid dysfunction and patient characteristics including age, sex, type of diabetes, and baseline serum thyrotropin concentration. Kaplan-Meier survival curves were generated for predictors of hypothyroidism. Results: Clinical records of 1101 patients were reviewed (595 men [54%] and 506 women [46%]). Mean age was 60.0 ±17 years. Two hundred twenty-three patients (20.3%) had type 1 DM and 878 (79.7%) had type 2 diabetes. Thyroid dysfunction was present in 136 patients (12.4%) at baseline and developed in 71 patients (6.4%) at follow-up (median duration, 37 months). Overt and subclinical hypothyroidism developed in 28 (2.5%) and 38 (3.5%) patients, respectively. Incident hypothyroidism was associated with baseline thyrotropin concentration greater than 2.2 mIU/L (relative risk, 10.4; confidence interval, 5.6-19.6; P |
| Databáze: | OpenAIRE |
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