Incidence of and survival after glottic squamous cell carcinoma in Denmark from 1971 to 2011:A report from the Danish Head and Neck Cancer Group
| Autor: | Hanne Primdahl, Nina Munk Lyhne, Jørgen Johansen, Elo Andersen, Jens Overgaard, Lisbeth Juhler Andersen, Claus Kristensen, Susanne Oksbjerg |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Oncology Glottis Cancer Research medicine.medical_specialty Denmark Population Kaplan-Meier Estimate Time-to-Treatment 03 medical and health sciences Age Distribution 0302 clinical medicine Internal medicine medicine Humans Registries Sex Distribution Stage (cooking) 030223 otorhinolaryngology education Laryngeal Neoplasms Aged Cause of death Aged 80 and over education.field_of_study Squamous Cell Carcinoma of Head and Neck business.industry Incidence Incidence (epidemiology) Head and neck cancer Hazard ratio Neoplasms Second Primary medicine.disease Glottic Squamous Cell Carcinoma Head and Neck Neoplasms 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Female business |
| Zdroj: | Lyhne, N M, Johansen, J, Kristensen, C A, Andersen, E, Primdahl, H, Andersen, L J, Oksbjerg, S & Overgaard, J 2016, ' Incidence of and survival after glottic squamous cell carcinoma in Denmark from 1971 to 2011 : A report from the Danish Head and Neck Cancer Group ', European Journal of Cancer, vol. 59, pp. 46-56 . https://doi.org/10.1016/j.ejca.2016.01.020 Lyhne, N M, Johansen, J, Kristensen, C A, Andersen, E, Primdahl, H, Andersen, L J, Oksbjerg, S & Overgaard, J 2016, ' Incidence of and survival after glottic squamous cell carcinoma in Denmark from 1971 to 2011-A report from the Danish Head and Neck Cancer Group ', European Journal of Cancer, vol. 59, pp. 46-56 . https://doi.org/10.1016/j.ejca.2016.01.020 Lyhne, N M, Johansen, J, Kristensen, C A, Andersen, E, Primdahl, H, Andersen, L J, Oksbjerg, S & Overgaard, J 2016, ' Incidence of and survival after glottic squamous cell carcinoma in Denmark from 1971 to 2011 : A report from the Danish Head and Neck Cancer Group ', European Journal of Cancer, vol. 59, no. May, pp. 46-56 . https://doi.org/10.1016/j.ejca.2016.01.020 |
| Popis: | AIM: To describe the incidence, disease-specific mortality (DSM), and overall survival (OS) of patients with glottic squamous cell carcinomas (SCC) in Denmark from 1971-2011 in a national population-based cohort of consecutive patients.MATERIALS AND METHODS: All patients diagnosed with glottic SCC stage I-IV between 1971 and 2011 in Denmark were included. Patients were identified from the Danish Head and Neck Cancer database, which has a coverage of approximately 100% of registered glottic cancer in Denmark. Information on vital status and cause of death were updated using patient charts and national registries.RESULTS: In total 5132 patients with glottic SCC were included. The yearly number of new cases increased from 107 in the 1970s to 139 in the 2000s. Overall, the incidence increased from 1.9 to 2.6 per 100,000, with a more prominent increase in men (3.5 to 4.7) compared with women (0.4 to 0.6). The 5-year DSM was 16% (15-17%) and the 5-year OS was 63% (61-64). The hazard rate of DSM adjusted for patient characteristics, tumour characteristics and waiting-time was significantly lower in the 2000s (p < 0.01), and the hazard rate of OS was significantly higher (p < 0.01) compared to the earlier decades. Longer waiting-time for treatment (>25 d) significantly increased DSM and reduced OS.CONCLUSION: Despite being highly avoidable with smoking cessation, the incidence of glottic SCC increased in Denmark from 1971-2011. The adjusted hazard rate of DSM and overall death after glottic SCC was significantly lower in the 2000s compared to previous decades. Waiting-time for treatment significantly influenced DSM and OS. |
| Databáze: | OpenAIRE |
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