Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay
| Autor: | Laura Corvette, Juan A. Castelán-Vega, Lev Sirota, Juan Arciniega |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Anthrax vaccines Hot Temperature Toxin Chemistry Immunogenicity Clinical Biochemistry Immunology fungi Anthrax Vaccines medicine.disease_cause Vaccine Research Virology complex mixtures Antibodies Bacterial Neutralization Microbiology Mice Drug Stability Neutralization Tests medicine Immunology and Allergy Potency Animals Antitoxins |
| Zdroj: | Clinical and vaccine immunology : CVI. 18(2) |
| ISSN: | 1556-679X |
| Popis: | We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge. |
| Databáze: | OpenAIRE |
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