Does childhood immunization against infectious diseases protect from the development of atopic disease?
| Autor: | Isabella Annesi-Maesano, Marie-Pierre Oryszczyn, Gilles Martignon |
|---|---|
| Přispěvatelé: | Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), G Martignon, MP Oryszczyn, Annesi-Maesano je |
| Rok vydání: | 2005 |
| Předmět: |
Hypersensitivity
Immediate Male Pediatrics Allergy MESH: Asthma Vaccination schedule Eczema MESH: Immunization Programs Atopy 0302 clinical medicine MESH: Child Prevalence MESH: Diphtheria-Tetanus-Pertussis Vaccine Immunology and Allergy Child Pertussis Vaccine education.field_of_study Bacterial Infections 3. Good health Vaccination MESH: BCG Vaccine Bacterial Vaccines BCG Vaccine MESH: Immunization Female MESH: Hypersensitivity Immediate medicine.medical_specialty Rhinitis Allergic Perennial Adolescent MESH: Bacterial Infections Atopic Rhinitis Immunology Population 03 medical and health sciences 030225 pediatrics medicine Humans education Diphtheria-Tetanus-Pertussis Vaccine MESH: Prevalence Asthma MESH: Adolescent MESH: Humans MESH: Rhinitis Allergic Perennial Immunization Programs business.industry medicine.disease MESH: Male MESH: Pertussis Vaccine MESH: Eczema 030228 respiratory system Immunization Pediatrics Perinatology and Child Health [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female MESH: Bacterial Vaccines |
| Zdroj: | Pediatric Allergy and Immunology Pediatric Allergy and Immunology, Wiley, 2005, 16 (3), pp.193-200. ⟨10.1111/j.1399-3038.2005.00254.x⟩ Pediatric Allergy and Immunology, 2005, 16 (3), pp.193-200. ⟨10.1111/j.1399-3038.2005.00254.x⟩ |
| ISSN: | 1399-3038 0905-6157 |
| DOI: | 10.1111/j.1399-3038.2005.00254.x |
| Popis: | International audience; The argument of whether early immunization against infections promotes allergy or protects from it is presently under debate. The relationship between childhood immunization and the development of atopic diseases (asthma, allergic rhinitis and eczema) was examined in a population-based sample of 718 adolescents by taking individual data drawn from personal paediatric records on the schedule and the type of vaccination into account. Atopic diseases were determined using a standardized questionnaire. After adjustment for sex, age, father's socioeconomic status and active smoking, adolescents having been vaccinated (n = 694) had a significant lower risk to suffer from asthma or atopic diseases than non-vaccinated adolescents did (n = 24) [odds ratio (OR) = 0.30; 95% CI: 0.10, 0.92]. The relationship did not depend on the disease against which the vaccine was used as prophylaxis, the observance of the vaccination schedule or the number of inoculations. A higher protection was observed in the case of live attenuated vaccines (oral poliomyelitis and bacilli Camille-Guerin; OR = 0.26; 95% CI: 0.08, 0.83). These results, in agreement with previous ecological data, support the hypothesis that early vaccines could promote Th1 proliferation in response to the infectious agent contained in it, which inhibits the enhancement of atopic manifestations. Further studies are needed to confirm the phenomenon. |
| Databáze: | OpenAIRE |
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