Analysis of the expression, function, prognosis and co-expression genes of DDX20 in gastric cancer
| Autor: | Yao Lin, Rongbo Lin, Shuyun Weng, Yan Ye, Fan Cai, Lilin Ge, Mei Zou, Haitao Niu, Qingshui Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
T cell
lcsh:Biotechnology Biophysics Biochemistry 03 medical and health sciences 0302 clinical medicine Immune system Structural Biology lcsh:TP248.13-248.65 Genetics Medicine Gene Survival analysis 030304 developmental biology ComputingMethodologies_COMPUTERGRAPHICS 0303 health sciences Progression business.industry digestive oral and skin physiology Cancer DEAD-box polypeptide 20 medicine.disease In vitro digestive system diseases Computer Science Applications Immune medicine.anatomical_structure 030220 oncology & carcinogenesis DDX20 Cancer research business Gastric cancer Function (biology) Biotechnology Research Article |
| Zdroj: | Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2453-2462 (2020) Computational and Structural Biotechnology Journal |
| ISSN: | 2001-0370 |
| Popis: | Graphical abstract DDX20 (DEAD-box polypeptide 20) is implicated in many cellular processes involving alteration of RNA secondary structure. The role of DDX20 in gastric cancer is still unknown. In the research, the expression of DDX20 and the functional roles of DDX20 in gastric cancer were detected. The increased DDX20 expression in gastric cancer tissue compared with normal gastric tissue was observed. Functional experiments indicated that DDX20 promoted gastric cancer MGC-803 and AGS cells growth, migration, and invasion in vitro. Surprisingly, survival analysis showed that high expression of DDX20 is a favorable prognostic factor for patients with gastric cancer. In addition, enrichment analysis revealed that there is a positive correlation between DDX20 expression and T cell activation in gastric cancer. but not in normal gastric tissues. Furthermore, we found that DDX20 expression level has significant positive correlations with activated CD8 + T cells and activated CD4 + T cells in gastric cancer. Therefore, we hypothesize that the prognostic role of DDX20 in gastric cancer patients may be due to patients with high DDX20 expression contained better immune activation. Taken together, these findings suggest that DDX20 can promote the progression of gastric cancer in vitro and its prognostic value in gastric cancer may be related to many factors, including immune activation. |
| Databáze: | OpenAIRE |
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