CD10 immunostaining of bile canaliculi in liver biopsies: change of staining pattern with the development of cirrhosis
| Autor: | A V Thillainaygam, D Peston, I M Murray-Lyon, F Gadir, Sami Shousha, D Bansi |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Histology Cirrhosis Adolescent Biopsy Intrahepatic bile ducts Biology Gastroenterology Pathology and Forensic Medicine Cholestasis Internal medicine Biomarkers Tumor medicine Carcinoma Humans Aged medicine.diagnostic_test Liver cell Bile Canaliculi Liver Neoplasms General Medicine Hepatitis C Middle Aged medicine.disease Immunohistochemistry Hepatocellular carcinoma Female Neprilysin Liver function tests Precancerous Conditions |
| Zdroj: | Histopathology. 45:335-342 |
| ISSN: | 1365-2559 0309-0167 |
| Popis: | Aims : This study was prompted by published observations concerning the absence of normal bile canalicular CD10 staining in some cases of primary liver cell carcinoma. Our aim was to investigate the possibility that this loss of staining occurs prior to the development of cancer. Methods and results : The study comprised 164 liver biopsies, including 96 from patients with hepatitis C infection of various grades and stages including nine cases with cirrhosis, 24 other cases of cirrhosis of other aetiology, five cases of primary liver carcinoma, 12 cases of metastatic carcinoma, as well as biopsies with a variety of other liver diseases. CD10 was demonstrated in paraffin sections using the avidin–biotin immunoperoxidase technique. In hepatitis C cases, a significant loss of the canalicular pattern was seen in four out of 41 (10%) biopsies with stages 0–1 compared with 25 out of 55 (45%) with stages 2–6 (P |
| Databáze: | OpenAIRE |
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