Tiagabine-induced stupor in patients with psychogenic nonepileptic seizures: nonconvulsive status epilepticus or encephalopathy?
| Autor: | Nabil J. Azar, Bassel Abou-Khalil, Amir Arain, Nandakumar Bangalore-Vittal |
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| Rok vydání: | 2012 |
| Předmět: |
Phenytoin
Adult Male Tiagabine Encephalopathy Nipecotic Acids Video Recording Status epilepticus Behavioral Neuroscience Epilepsy Status Epilepticus Medicine Psychogenic disease Humans Stupor business.industry Toxic encephalopathy Electroencephalography Middle Aged medicine.disease Brain Waves Neurology Conversion Disorder Anesthesia Anticonvulsants Female Neurotoxicity Syndromes Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Epilepsybehavior : EB. 27(2) |
| ISSN: | 1525-5069 |
| Popis: | Background Nonconvulsive status epilepticus has been rarely reported with tiagabine (TGB) use. Methods We report findings from continuous video-EEG monitoring and serial neurological examinations during prolonged episodes of stupor associated with TGB use in three patients who did not have epilepsy. Results All three patients had emergence of new type of events after starting TGB treatment. All three patients had gradual decline in responsiveness to verbal stimuli, intermittent twitching of the upper extremities, and urinary incontinence. The corresponding EEG showed gradual build-up of generalized bisynchronous delta-wave activity with subsequent intermingled sharp transients. Two patients did not respond to IV lorazepam, one of whom also did not respond to IV phenytoin. The EEG slowly normalized in conjunction with associated clinical improvement. Habitual seizures were found to be psychogenic, with no interictal evidence for epilepsy. Conclusion Tiagabine-related stupor may represent a form of toxic encephalopathy in some cases rather than nonconvulsive status epilepticus. |
| Databáze: | OpenAIRE |
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