Low eicosapentaenoic acid and gamma-linolenic acid levels in breast adipose tissue are associated with inflammatory breast cancer
| Autor: | Marie Chas, Stephan Chevalier, Flavie Arbion, Caroline Goupille, Lobna Ouldamer, Philippe Bougnoux, Michelle Pinault, Marie Lise Jourdan |
|---|---|
| Přispěvatelé: | Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Bretonneau, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Eicosapentaenoic acid
medicine.medical_treatment [SDV]Life Sciences [q-bio] Adipose tissue chemistry.chemical_compound 0302 clinical medicine Breast cancer n-3PUFA Breast 030212 general & internal medicine skin and connective tissue diseases Aged 80 and over chemistry.chemical_classification General Medicine Middle Aged 3. Good health [SDV] Life Sciences [q-bio] Adipose Tissue 030220 oncology & carcinogenesis Female Inflammatory Breast Neoplasms Polyunsaturated fatty acid Adult medicine.medical_specialty Chromatography Gas Breast surgery Breast Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.BC]Life Sciences [q-bio]/Cellular Biology Inflammatory breast cancer 03 medical and health sciences [SDV.CAN] Life Sciences [q-bio]/Cancer Internal medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology gamma-Linolenic Acid gamma-Linolenic acid [SDV.BC] Life Sciences [q-bio]/Cellular Biology Aged Retrospective Studies Inflammation business.industry Fatty acid medicine.disease [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Endocrinology chemistry Surgery business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | The Breast The Breast, 2019, 45, pp.113-117. ⟨10.1016/j.breast.2019.04.001⟩ |
| DOI: | 10.1016/j.breast.2019.04.001⟩ |
| Popis: | Objective Since it is thought that breast adipose tissue could influence breast cancer clinical presentation, we wanted to characterize specifically the relationship between breast adipose tissue fatty acid profile and Inflammatory Breast cancer (IBC). Methods Two hundred thirty-four women presenting with breast cancer were managed in our centre between January 2009 and December 2011. Breast adipose tissue specimens were collected during breast surgery. We established the biochemical profile of adipose tissue fatty acids (FA) by gas chromatography and assessed whether there were differences in function of the presence of breast inflammation or not. Results We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Inversely, an increase in palmitic acid levels was associated with IBC. Conclusion These differences in lipid content may contribute to the occurrence of breast cancer inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|