Acute variation of estimated glomerular filtration rate following a half-marathon run
| Autor: | Gian Luca Salvagno, Federico Schena, Martina Montagnana, Gian Cesare Guidi, Giuseppe Lippi, Giuseppe Banfi, Matteo Gelati, Cantor Tarperi |
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| Přispěvatelé: | G., Lippi, F., Schena, G. L., Salvagno, C., Tarperi, M., Montagnana, M., Gelati, Banfi, Giuseppe, G. C., Guidi |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Sports medicine Creatinine EGFR GFR Glomerular function rate Sports Analysis of Variance Exercise Exercise Tolerance Humans Middle Aged Muscle Contraction Muscle Skeletal Pilot Projects Running Glomerular Filtration Rate Urology Renal function Physical Therapy Sports Therapy and Rehabilitation Physical exercise urologic and male genital diseases Plasma volume chemistry.chemical_compound creatinine GFR glomerular function rate EGFR sports Statistical significance Internal medicine Medicine Orthopedics and Sports Medicine Exercise physiology business.industry Skeletal Endocrinology chemistry Muscle Analysis of variance business |
| Popis: | The accurate estimation of glomerular filtration rate (GFR) is pivotal in sports medicine. However, there is controversial information on the acute influence of physical exercise on kidney function in healthy athletes. The estimated GFR (EGFR) was assessed by the recommended Modification of Diet in Renal Disease (MDRD) equation before a 21-km half-marathon, at the end, and 3, 6, 24 hrs thereafter on 17 trained, middle-aged males. Results were corrected for plasma volume changes. The mean EGFR at the baseline was 76 mL/min/1.73 m (2); it decreased at the end of the run (62 mL/min/1.73 m (2)) and for the following 3 hrs (68 mL/min/1.73 m (2)) and 6 hrs (70 mL/min/1.73 m (2)), though statistical significance was only achieved immediately after the run (mean decrease 16 %, p < 0.01). The frequency of athletes with EGFR below the normal threshold was higher than the baseline immediately after the race and for the following 6 hrs. Twenty-four hours after the run, the EGFR had returned to values similar and nonsignificantly different from those recorded at the baseline. These results attest that medium to high strains of running in healthy, middle-aged, trained individuals do not cause renal damage, but a limited and temporary decline in renal function. |
| Databáze: | OpenAIRE |
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