Recent Mumps Outbreaks in Vaccinated Populations: No Evidence of Immune Escape
Autor: | Laurie Ngo, Cheryl Zhang, Christian Sauder, Bert K. Rima, Steven A. Rubin, W. Paul Duprex, Malen A. Link |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Male
Immunology Molecular Sequence Data Mumps virus Biology medicine.disease_cause Antibodies Viral Microbiology Measles Rubella Virus Disease Outbreaks Immunity Virology Vaccines and Antiviral Agents medicine Humans Neutralizing antibody Child Mumps Phylogeny Vaccination Outbreak medicine.disease Antibodies Neutralizing United States Insect Science Child Preschool biology.protein Female Measles-Mumps-Rubella Vaccine |
Popis: | Recently, numerous large-scale mumps outbreaks have occurred in vaccinated populations. Clinical isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vaccine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity. To investigate this concern, sera obtained from children 6 weeks after receipt of measles, mumps, and rubella (MMR) vaccine were tested for the ability to neutralize a carefully selected group of genetically diverse mumps virus strains. Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape. |
Databáze: | OpenAIRE |
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