SICI during changing brain states: Differences in methodology can lead to different conclusions

Autor: John C. Rothwell, Jaime Ibáñez, Varshini Paraneetharan, Danny Spampinato
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_treatment
0302 clinical medicine
Conditioning
Psychological
GABAergic Neurons
electromyogram
EMG
Chemistry
General Neuroscience
05 social sciences
Brain
Transcranial Magnetic Stimulation
motor evoked potential
MEP
Inhibition
Psychological
first dorsal interosseous
FDI
Reaction time
RT
Female
Adult
Movement
Transcranial magnetic stimulation
Short intra-cortical inhibition
Movement preparation
Preparatory inhibition
Biophysics
warned simple reaction time task
wSRTT
warning stimulus
WS
Stimulus (physiology)
Inhibitory postsynaptic potential
050105 experimental psychology
Article
lcsh:RC321-571
03 medical and health sciences
imperative stimulus
IS
medicine
Reaction Time
Humans
0501 psychology and cognitive sciences
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
test stimulus
TS
transcranial magnetic stimulation
TMS
motor cortex
M1
Neural Inhibition
Evoked Potentials
Motor
conditioning stimulus
CS
Brain state
Intracortical inhibition
Conditioning
short interval intra-cortical inhibition
SICI
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Zdroj: Brain Stimulation
Brain Stimulation, Vol 13, Iss 2, Pp 353-356 (2020)
ISSN: 1876-4754
1935-861X
Popis: Background Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of conditioning stimulus so that inhibition can be compared in different brain states. Objective Here, we show that this approach may sometimes be inadequate since distinct conclusions can be drawn if a different CS intensity is used. Methods We measured SICI using a range of CS intensities at rest and during a warned simple reaction time task. Conclusions Our results show that SICI changes that occurred during the task could be either larger or smaller than at rest depending on the intensity of the CS. These findings indicate that careful interpretation of results are needed when a single intensity of CS is used to measure task-related physiological changes.
Highlights • We measured SICI using several conditioning stimulus (CS) intensities at rest and during a warned simple reaction time task. • Pre-movement SICI changes can be either larger or smaller than at rest depending on the intensity of the CS used. • Careful interpretation of SICI is needed when a single intensity of CS is used to measure task-related physiological changes.
Databáze: OpenAIRE
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