Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae)
| Autor: | J. Modupe Makinde, Olumayokun A. Olajide, David T. Okpako |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
Cotton pellet Combretaceae biology Traditional medicine medicine.drug_class Immunology Vascular permeability biology.organism_classification medicine.disease Anti-inflammatory Carrageenan Acetic acid chemistry.chemical_compound chemistry Biochemistry Granuloma medicine Combretum micranthum Pharmacology (medical) |
| Zdroj: | Inflammopharmacology. 11(3) |
| ISSN: | 0925-4692 |
| Popis: | A methanol extract of Combretum micranthum leaves was studied for anti-inflammatory activity in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice. The effect of the extract on cellular-type inflammation was also investigated in the cotton pellet granuloma in rats. The extract (50, 100 mg/kg) significantly (P < 0.05) inhibited oedema production induced by carrageenan in rats. Increased vascular permeability caused by acetic acid injection was also inhibited by the extract, within the same dose range. C. micranthum extract (100 mg/kg) inhibited granuloma formation in rats to a similar degree as indomethacin (5 mg/kg). These results provide evidence for the anti-inflammatory property of C. micranthum leaves. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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