Do uterine natural killer cell numbers in peri-implantation endometrium predict hypertensive disorder in pregnancy in women with a history of reproductive failure?
| Autor: | Susan Laird, Najat Mariee, Tin-Chiu Li, Bethan Archer, Alice Wai Yee Wong |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Gestational hypertension
Adult medicine.medical_specialty Abortion Habitual Stromal cell medicine.medical_treatment Biopsy Immunology Endometrium Pre-Eclampsia Pregnancy Recurrent miscarriage medicine Immunology and Allergy Humans Embryo Implantation Lymphocyte Count Retrospective Studies Gynecology In vitro fertilisation business.industry Incidence (epidemiology) Uterus Obstetrics and Gynecology Hypertension Pregnancy-Induced medicine.disease CD56 Antigen Killer Cells Natural medicine.anatomical_structure Reproductive Medicine embryonic structures Hypertensive disease of pregnancy Female business |
| Zdroj: | Journal of reproductive immunology. 106 |
| ISSN: | 1872-7603 |
| Popis: | The aim of this study was to investigate whether or not increased uterine natural killer (uNK) cell numbers in the peri-implantation endometrium are associated with an increased risk of hypertensive disorders in a subsequent pregnancy. This is a retrospective study including 80 women with a history of unexplained recurrent miscarriage or recurrent implantation failure. Precisely timed endometrial biopsies were obtained from women 7-9 days after the luteinising hormone surge. uNK cells were immunostained for CD56+ and expressed as a percentage of total stromal cells. Patients were defined as having a high uNK cell count if the percentage of total stromal cells was more than 13.9%. Five out of 29 (17.2%) women in the high uNK cell count group and 5 out of 51 (9.8%) women in the normal uNK cell count group developed gestational hypertension. Pre-eclampsia was diagnosed in 2 (6.9%) patients in the high uNK cell count group and 1 (2.0%) patient from the normal uNK cell count group. There was no significant difference in the incidence of either gestational hypertension (P=0.483) and pre-eclampsia (P=0.296) between groups. The overall incidence of hypertensive disease in women with high uNK cell count (24.1%) was two times higher than women with normal uNK cell count (11.8%), but it was not statistically significant (P=0.208). An increased uNK cells count in the peri-implantation period in a cycle prior to conception did not appear to significantly increase the likelihood of hypertensive disease of pregnancy. |
| Databáze: | OpenAIRE |
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