Efficacy of candesartan cilexetil in hypertensive patients with or without diabetes
| Autor: | Ramzi El Feghali, Sophie Nisse-Durgeat, Roland Asmar |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Physiology business.industry Biphenyl Compounds Tetrazoles Middle Aged medicine.disease Candesartan Double-Blind Method Diabetes mellitus Internal medicine Hypertension Diabetes Mellitus Internal Medicine medicine Humans Benzimidazoles Female Cardiology and Cardiovascular Medicine business Antihypertensive Agents Randomized Controlled Trials as Topic medicine.drug |
| Zdroj: | Journal of Hypertension. 25:A9 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/01.hjh.0000298992.09892.a6 |
| Popis: | To assess the effect of an ARB, candesartan cilexetil (CC), on blood pressure (BP) from 5 double-blind, randomised, studies in hypertensive patients.Similar design was used in the 5 selected studies. Following 2-4 weeks run-in period with placebo, patients were randomised to receive the double-blind treatment. BP were assessed at inclusion, after 4-6 weeks and at the end (8-12 weeks). Depending on the BP response, dosage of CC 8 mg was doubled at the follow-up visit if BPor=140/90 mmHg.702 patients were randomised in CC group of whom 22% (153) were diabetic. Mean BP was 160 +/- 13/94 +/- 10/65 +/- 14 mmHg for SBP/DBP/PP at inclusion and were significantly reduced to 141 +/- 15/83 +/- 10/58 +/- 13 mmHg (p0.001) after 8-12 weeks. The results according to the diabetes status are presented in the table below: [table: see text]Results of this meta analysis analysis performed on individual data show that CC reduces significantly BP in hypertensive population with a significant decrease in the diabetic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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