Sound transmission in human thorax through airway insonification: an experimental and computational study with diagnostic applications
| Autor: | Zoujun Dai, Harish Palnitkar, Richard H. Sandler, Ying Peng, Thomas J. Royston, Robert A. Balk, Hansen A. Mansy, Brian Henry |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Thorax
computational modeling Models Anatomic tumor Materials science Lung Neoplasms Sound transmission class pneumothorax 0206 medical engineering Finite Element Analysis Biomedical Engineering 02 engineering and technology Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Laser-Doppler Flowmetry Humans Computer Simulation Computer simulation fibrosis Acoustics medicine.disease 020601 biomedical engineering Idiopathic Pulmonary Fibrosis Computer Science Applications Magnetic resonance elastography lung acoustics Wavelength Pneumothorax Mechanical wave Longitudinal wave Biomedical engineering |
| Zdroj: | Medical & biological engineering & computing |
| ISSN: | 1741-0444 0140-0118 |
| Popis: | Pulmonary diseases and injury lead to structural and functional changes in the lung parenchyma and airways, often resulting in measurable sound transmission changes on the chest wall surface. Additionally, noninvasive imaging of externally driven mechanical wave motion in the chest (e.g., using magnetic resonance elastography) can provide information about lung stiffness and other structural property changes which may be of diagnostic value. In the present study, a comprehensive computational simulation (in silico) model was developed to simulate sound wave propagation in the airways, parenchyma, and chest wall under normal and pathological conditions that create distributed structural (e.g., pneumothoraces) and diffuse material (e.g., fibrosis) changes, as well as a localized structural and material changes as may be seen with a neoplasm. Experiments were carried out in normal subjects to validate the baseline model. Sound waves with frequency content from 50 to 600 Hz were introduced into the airways of three healthy human subjects through the mouth, and transthoracic transmitted waves were measured by scanning laser Doppler vibrometry at the chest wall surface. The computational model predictions of a frequency-dependent decreased sound transmission due to pneumothorax were consistent with experimental measurements reported in previous work. Predictions for the case of fibrosis show that while shear wave motion is altered, changes to compression wave propagation are negligible, and thus insonification, which primarily drives compression waves, is not ideal to detect the presence of fibrosis. Results from the numerical simulation of a tumor show an increase in the wavelength of propagating waves in the immediate vicinity of the tumor region. Graphical Abstract |
| Databáze: | OpenAIRE |
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