20% Human Albumin Solution Fluid Bolus Administration Therapy in Patients After Cardiac Surgery (the HAS FLAIR Study)
| Autor: | Jeffrey J. Presneill, Rinaldo Bellomo, Ashley St. John, Michael Bailey, Marc Morales-Codina, Adam M. Deane, James Anstey, Christopher MacIsaac, James Tatoulis, Joel Greaney, Geoffrey Wigmore |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation Cardiac index Hemodynamics Pilot Projects Serum Albumin Human 030204 cardiovascular system & hematology Fluid-attenuated inversion recovery law.invention 03 medical and health sciences Postoperative Complications 0302 clinical medicine 030202 anesthesiology law Hypovolemia medicine Humans Cardiac Surgical Procedures Infusions Intravenous Retrospective Studies Postoperative Care business.industry Albumin Crystalloid Solutions Middle Aged Water-Electrolyte Balance Intensive care unit Cardiac surgery Intensive Care Units Treatment Outcome Anesthesiology and Pain Medicine Anesthesia Fluid Therapy Female Hypotension medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 33:2920-2927 |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/j.jvca.2019.03.049 |
| Popis: | To compare the effects of fluid bolus therapy using 20% albumin versus crystalloid on fluid balance, hemodynamic parameters, and intensive care unit (ICU) treatment effects in post-cardiac surgery patients.Sequential period open-label pilot study.University teaching hospital.One hundred adult cardiac surgery patients who were prescribed fluid bolus therapy to correct hypotension or perceived hypovolemia or to optimize cardiac index during the first 24 hours in the ICU.The first 50 patients were treated with crystalloid fluid bolus therapy in the first period (control), and 50 patients with up to 2 treatments of 100 mL of 20% albumin fluid bolus therapy in the second period (intervention), followed by crystalloid therapy if needed.Demographic characteristics were similar at baseline. The intervention was associated with a less positive median fluid balance in the first 24 hours (albumin: 1,100 [650-1,960] v crystalloid: 1,970 [1,430-2,550] p = 0.001), fewer episodes of fluid bolus therapy (3 [2-5] v 5 [4-7]; p0.0001) and a lesser volume of fluid bolus therapy (700 [200-1,450] v 1,500 mL/24 h [1,100-2,250]; p0.0001). The intervention also was associated with a decreased median overall dose of norepinephrine in the first 24 hours of ICU stay (19 [0-52] v 47 µg/kg/24 hours [0-134]; p = 0.025) and shorter median time to cessation of norepinephrine (17 [5-28] v 28 hours [20-48]; p = 0.002).Post-cardiac surgery fluid bolus therapy with 20% albumin when compared with crystalloid fluid resulted in less positive fluid balance as well as several hemodynamic and potential ICU treatment advantages. |
| Databáze: | OpenAIRE |
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