| Autor: |
Fernando Doñate, David R. Stover, Brian A. Mendelsohn, Roland Luethy, Sung-Ju Moon, Josh Snyder, Linnette Capo, René Hubert, Hector Aviña, Sher Karki, Pia Challita-Eid, Faisal Malik, Jeffrey Coleman, Karen Morrison, Peng Yang, Jimmy Ou, Jenny Nater, Zhilan Zeng, Sara Gulesserian, John Atkinson, Hui Zhao |
| Rok vydání: |
2023 |
| Popis: |
Supplemental tables 1-5: Table 1: Characteristics of peptide modified ADCs tested and IC50 in the HCEC and KU812 assays. Table 2: Characteristics. of PEG modified ADCs tested and data in the HCEC and KU812 assays. Table 3: Characteristics of mutated ADCs tested in the HCEC and KU812 cytotoxicity assays. Table 4: Pharmacokinetic parameters in mice and rabbits. ADC and Tab. Table 5: Body gain weight of rabbits treated with AGS-16C3F and other ADCs. Supplemental Materials and Methods Summplemental Figure Legends Supplemental figures 1-4: Fig S1: Lack of ENPP3 expression in corneas from humans and cynomolgus monkeys. Fig S2: Characterization of human corneal epithelial cells (HCEC). Fig S3: Target expression in HCEC and normal corneal epithelial cells by microarray analysis. Fig S4: Binding of AGS-16C3F to primary cells. References |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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