Applications of brain organoids in neurodevelopment and neurological diseases
Autor: | Yuxiang Liu, Nan Sun, Chuanlu Jiang, Dan Song, Jinquan Cai, Xiangqi Meng |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Pluripotent Stem Cells
Cell type Brain development Endocrinology Diabetes and Metabolism Clinical Biochemistry Pluripotent stem cell Review Biology Organoid medicine Humans Pharmacology (medical) Induced pluripotent stem cell Molecular Biology Embryonic Stem Cells Biomedicine Structural organization business.industry Brain organoid Biochemistry (medical) Brain Cell Differentiation Cell Biology General Medicine Human brain Embryonic stem cell Organoids medicine.anatomical_structure Medicine business Glioblastoma Neuroscience Neurological disorders |
Zdroj: | Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-16 (2021) Journal of Biomedical Science |
ISSN: | 1423-0127 |
Popis: | A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant and continue to improve, and now, an in vivo vascularized brain organoid has been encouragingly reported. The combination of brain organoids with immune-staining and single-cell sequencing technology facilitates our understanding of brain organoids, including the structural organization and the diversity of cell types. Recent publications have reported that brain organoids can mimic the dynamic spatiotemporal process of early brain development, model various human brain disorders, and serve as an effective preclinical platform to test and guide personalized treatment. In this review, we introduce the current state of brain organoid differentiation strategies, summarize current progress and applications in the medical domain, and discuss the challenges and prospects of this promising technology. |
Databáze: | OpenAIRE |
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