Vestibular nucleus N-methyl-d-aspartate receptors contribute to spontaneous nystagmus generation following unilateral labyrinthectomy in Guinea pigs
| Autor: | Andrew J. Sansom, Cynthia L. Darlington, Richard Laverty, Paul F. Smith |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Calcium Channels L-Type Nifedipine Guinea Pigs Receptors N-Methyl-D-Aspartate Functional Laterality Guinea pig Nystagmus Physiologic Vestibular nuclei Internal medicine medicine Animals Receptor Chemistry General Neuroscience Glutamate receptor Antagonist Vestibular pathway Stereoisomerism Calcium Channel Blockers Endocrinology Ear Inner Anesthesia NMDA receptor Vestibule Labyrinth Dizocilpine Maleate medicine.drug |
| Zdroj: | Neuroscience Letters. 283:117-120 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(00)00933-2 |
| Popis: | We investigated the effects of a non-competitive N -methyl- d -aspartate (NMDA) receptor/channel antagonist ((+)MK-801)) or an L-type Ca 2+ channel antagonist (nifedipine), delivered into the ipsilateral vestibular nucleus complex (VNC) before a unilateral labyrinthectomy (UL), on spontaneous nystagmus (SN) generation. Guinea pigs received either (+)MK-801 (5 or 12.5 μg); the less active enantiomer, (-)MK-801 (5 or 12.5 μg); nifedipine (5 or 10 μg); or vehicle, via cannula in the ipsilateral VNC. (+)MK-801, but not nifedipine, significantly decreased mean SN frequencies at 6 h post-UL, compared to controls ( P ) and reduced the rate of SN compensation ( P ). These results suggest that the SN expression is partly induced by NMDA receptor activation in the ipsilateral VNC at the time of the UL. |
| Databáze: | OpenAIRE |
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